Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.

Journal Article (Clinical Trial;Journal Article)

This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.

Full Text

Duke Authors

Cited Authors

  • Raft, D; Davidson, J; Wasik, J; Mattox, A

Published Date

  • 1981

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 122 - 126

PubMed ID

  • 7231652

International Standard Serial Number (ISSN)

  • 0302-282X

Digital Object Identifier (DOI)

  • 10.1159/000117841


  • eng

Conference Location

  • Switzerland