Relationship between response to phenelzine and MAO inhibition in a clinical trial of phenelzine, amitriptyline and placebo.


Journal Article

This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.

Full Text

Duke Authors

Cited Authors

  • Raft, D; Davidson, J; Wasik, J; Mattox, A

Published Date

  • 1981

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 122 - 126

PubMed ID

  • 7231652

Pubmed Central ID

  • 7231652

International Standard Serial Number (ISSN)

  • 0302-282X

Digital Object Identifier (DOI)

  • 10.1159/000117841


  • eng

Conference Location

  • Switzerland