Antidepressant drug therapy in psychotic depression.

Journal Article (Clinical Trial;Journal Article)

Imipramine and phenelzine were ineffective in the treatment of five primary unipolar depressives with delusions, even when plasma levels of imipramine and desmethylimipramine or activity of platelet monoamine oxidase suggested that an adequate dose of drug had been given. Four patients went on to receive ECT and all responded well. Five non-delusional patients responded satisfactorily to the antidepressant drug given. Nine out of ten subjects were women. Non-delusional patients showed some placebo response. ECT is considered to be the treatment of choice in the acute phase of delusional depression in women.

Full Text

Duke Authors

Cited Authors

  • Davidson, JR; McLeod, MN; Kurland, AA; White, HL

Published Date

  • November 1977

Published In

Volume / Issue

  • 131 /

Start / End Page

  • 493 - 496

PubMed ID

  • 338082

International Standard Serial Number (ISSN)

  • 0007-1250

Digital Object Identifier (DOI)

  • 10.1192/bjp.131.5.493


  • eng

Conference Location

  • England