Catechol-O-methyltransferase activity and classification of depression.

Journal Article (Journal Article)

Red blood cell catechol-O-methyltransferase (COMT) activity was compared across different depressive diagnoses. In a sample of 88 depressed inpatients, using defined criteria, no difference was found in respect of enzyme activity and the following categories: primary, secondary, delusional, nondelusional, endogenous, nonendogenous (neurotic), characterological depressions. COMT did not vary with age or sex. A significant increase in COMT activity was noted in agitated, depressed males, as compared to other groups.

Full Text

Duke Authors

Cited Authors

  • Davidson, JR; McLeod, MN; Turnbull, CD; White, HL; Feuer, EJ

Published Date

  • December 1979

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 937 - 942

PubMed ID

  • 508884

International Standard Serial Number (ISSN)

  • 0006-3223


  • eng

Conference Location

  • United States