Catechol O-methyltransferase in red blood cells of schizophrenic, depressed, and normal human subjects.

Journal Article

Catechol O-methyltransferase of lysed human red blood cells was assayed under optimal conditions, using saturating concentrations of the substrates, S-adenosyl-L-methionine and 3-4-dihydroxybenzoic acid. The mean enzyme activity found in 24 normal subjects was 29-2 nmol/hr/ml RBC. The mean activity in blood of 33 female unipolar depressives was not significantly different from normal. However, higher enzyme activities were observed in the blood of 11 schizophrenic patients (38-9 nmol/hr/ml RBC). Partially purified enzyme preparations from blood of normal and schizophrenic individuals were indistinguishable with respect to substrate specificities, isoelectric pH values, and ratios of the two O-methylated products. Therefore it is unlikely that any defect in O-methylation which may occur in schizophrenia can be attributed to a change in the intrinsic properties of erythrocyte catechol O-methyltransferase.

Full Text

Duke Authors

Cited Authors

  • White, HL; McLeod, MN; Davidson, JR

Published Date

  • February 1, 1976

Published In

Volume / Issue

  • 128 /

Start / End Page

  • 184 - 187

PubMed ID

  • 3250

Electronic International Standard Serial Number (EISSN)

  • 1472-1465

International Standard Serial Number (ISSN)

  • 0007-1250

Digital Object Identifier (DOI)

  • 10.1192/bjp.128.2.184

Language

  • eng