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Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies.

Publication ,  Journal Article
Stein, DJ; Davidson, J; Seedat, S; Beebe, K
Published in: Expert Opin Pharmacother
October 2003

Post-traumatic stress disorder (PTSD) is increasingly understood to be a medical disorder characterised by particular psychobiological dysfunctions that respond to specific treatments. Paroxetine is a selective serotonin re-uptake inhibitor that has been found effective in the treatment of major depression as well as a range of anxiety disorders. This paper reviews data on the use of paroxetine for the treatment of adult PTSD. There have been three 12-week, placebo-controlled studies of paroxetine in PTSD. As these followed a partly similar design, a pooled analysis of the studies is possible and is reported here. Paroxetine is effective in the short-term treatment of PTSD, resulting in significantly better response and remission rates than placebo, improving sleep disturbance and reducing each of the symptom clusters of PTSD, as well as the disability associated with this condition. The medication is effective in both male and female PTSD patients and whether or not there are comorbid disorders such as depression.

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Published In

Expert Opin Pharmacother

DOI

ISSN

1465-6566

Publication Date

October 2003

Volume

4

Issue

10

Start / End Page

1829 / 1838

Location

England

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Selective Serotonin Reuptake Inhibitors
  • Randomized Controlled Trials as Topic
  • Placebos
  • Pharmacology & Pharmacy
  • Paroxetine
  • Humans
  • Administration, Oral
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Stein, D. J., Davidson, J., Seedat, S., & Beebe, K. (2003). Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies. Expert Opin Pharmacother, 4(10), 1829–1838. https://doi.org/10.1517/14656566.4.10.1829
Stein, Dan J., Jonathan Davidson, Soraya Seedat, and Katherine Beebe. “Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies.Expert Opin Pharmacother 4, no. 10 (October 2003): 1829–38. https://doi.org/10.1517/14656566.4.10.1829.
Stein DJ, Davidson J, Seedat S, Beebe K. Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies. Expert Opin Pharmacother. 2003 Oct;4(10):1829–38.
Stein, Dan J., et al. “Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies.Expert Opin Pharmacother, vol. 4, no. 10, Oct. 2003, pp. 1829–38. Pubmed, doi:10.1517/14656566.4.10.1829.
Stein DJ, Davidson J, Seedat S, Beebe K. Paroxetine in the treatment of post-traumatic stress disorder: pooled analysis of placebo-controlled studies. Expert Opin Pharmacother. 2003 Oct;4(10):1829–1838.

Published In

Expert Opin Pharmacother

DOI

ISSN

1465-6566

Publication Date

October 2003

Volume

4

Issue

10

Start / End Page

1829 / 1838

Location

England

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Selective Serotonin Reuptake Inhibitors
  • Randomized Controlled Trials as Topic
  • Placebos
  • Pharmacology & Pharmacy
  • Paroxetine
  • Humans
  • Administration, Oral
  • 3214 Pharmacology and pharmaceutical sciences