Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression.

Journal Article (Journal Article)

A case report is described wherein the monoamine oxidase inhibitor phenelzine was administered for 10 months at different doses. Drug treatment in the initial part of the study was double blind. Weekly psychotherapy was instituted at the point of symptomatic recovery. At a reduced dose, in month 3, the patient experienced a relapse in depression. While platelet monoamine oxidase inhibition was greater than 80 per cent the patient was well, but at the point of relapse, inhibition was 14 per cent. Clinical ratings at relapse (Beck and SCL-90 scales) revealed greater readiness by the patient to report psychological discomfort compared with the original interview. The combined effects of psychotherapy and pharmacotherapy were felt to be responsible for this change. However, psychotherapy in this form and duration did not prevent relapse, which depended upon maintaining an adequate dose of phenelzine.

Full Text

Duke Authors

Cited Authors

  • Davidson, J; Raft, D; Freeman, C

Published Date

  • October 1, 1979

Published In

Volume / Issue

  • 167 / 10

Start / End Page

  • 632 - 634

PubMed ID

  • 114605

International Standard Serial Number (ISSN)

  • 0022-3018

Digital Object Identifier (DOI)

  • 10.1097/00005053-197910000-00008


  • eng

Conference Location

  • United States