Differential response to placebo among patients with social phobia, panic disorder, and obsessive-compulsive disorder.
(Clinical Trial;Journal Article)
OBJECTIVE: Placebo effects in treatment of three anxiety disorders were compared. METHOD: Treatment response and patients' treatment expectancy were examined by using data from 70 patients with obsessive-compulsive disorder, social phobia, or panic disorder who received placebo in three randomized, controlled trials comparing cognitive behavior therapy, medication, and their combination to placebo. RESULTS: Patients with obsessive-compulsive disorder were less likely to respond to placebo than patients with generalized social phobia or panic disorder. Differential expectancy did not account for these findings. CONCLUSIONS: Further examination of the placebo effect across the anxiety disorders may elucidate maintenance mechanisms of these disorders and have implications for development of more effective treatments.
Huppert, JD; Schultz, LT; Foa, EB; Barlow, DH; Davidson, JRT; Gorman, JM; Shear, MK; Simpson, HB; Woods, SW
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