MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.

Journal Article

In a pilot study, 32 patients with mixed states of anxiety, depression, somatization and panic received amitriptyline for 4 weeks, the dose ranging from 50 to 300 mg/day. Steady-state plasma levels of the drug and activity of platelet monoamine oxidase were measured after 4 weeks. Clinical change was rated, using the SCL-90. Amitriptyline produced a small but significant inhibition of platelet monoamine oxidase activity (range 1.4--82%). A significant positive correlation was noted between MAO inhibition and improvement on somatization, and psychological and panic-phobic components of anxiety, but not for depression. No significant correlations were observed between improvement and combined or separate ami- + nortriptyline plasma levels.

Full Text

Duke Authors

Cited Authors

  • Davidson, J; Linnoila, M; Raft, D; Turnbull, CD

Published Date

  • February 1981

Published In

Volume / Issue

  • 63 / 2

Start / End Page

  • 147 - 152

PubMed ID

  • 7234472

Electronic International Standard Serial Number (EISSN)

  • 1600-0447

International Standard Serial Number (ISSN)

  • 0001-690X

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0447.1981.tb00660.x

Language

  • eng