Combined use of an electrostatic precipitator and a high-efficiency particulate air filter in building ventilation systems: Effects on cardiorespiratory health indicators in healthy adults.


Journal Article

High-efficiency particulate air (HEPA) filtration in combination with an electrostatic precipitator (ESP) can be a cost-effective approach to reducing indoor particulate exposure, but ESPs produce ozone. The health effect of combined ESP-HEPA filtration has not been examined. We conducted an intervention study in 89 volunteers. At baseline, the air-handling units of offices and residences for all subjects were comprised of coarse, ESP, and HEPA filtration. During the 5-week long intervention, the subjects were split into 2 groups, 1 with just the ESP removed and the other with both the ESP and HEPA removed. Each subject was measured for cardiopulmonary risk indicators once at baseline, twice during the intervention, and once 2 weeks after baseline conditions were restored. Measured indoor and outdoor PM2.5 and ozone concentrations, coupled with time-activity data, were used to calculate exposures. Removal of HEPA filters increased 24-hour mean PM2.5 exposure by 38 (95% CI: 31, 45) μg/m3 . Removal of ESPs decreased 24-hour mean ozone exposure by 2.2 (2.0, 2.5) ppb. No biomarkers were significantly associated with HEPA filter removal. In contrast, ESP removal was associated with a -16.1% (-21.5%, -10.4%) change in plasma-soluble P-selectin and a -3.0% (-5.1%, -0.8%) change in systolic blood pressure, suggesting reduced cardiovascular risks.

Full Text

Duke Authors

Cited Authors

  • Day, DB; Xiang, J; Mo, J; Clyde, MA; Weschler, CJ; Li, F; Gong, J; Chung, M; Zhang, Y; Zhang, J

Published Date

  • May 2018

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 360 - 372

PubMed ID

  • 29288500

Pubmed Central ID

  • 29288500

Electronic International Standard Serial Number (EISSN)

  • 1600-0668

International Standard Serial Number (ISSN)

  • 0905-6947

Digital Object Identifier (DOI)

  • 10.1111/ina.12447


  • eng