Demographic and clinical features of neuromyelitis optica: A review.

Journal Article (Journal Article;Review)

The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.

Full Text

Duke Authors

Cited Authors

  • Pandit, L; Asgari, N; Apiwattanakul, M; Palace, J; Paul, F; Leite, MI; Kleiter, I; Chitnis, T; GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica,

Published Date

  • June 2015

Published In

Volume / Issue

  • 21 / 7

Start / End Page

  • 845 - 853

PubMed ID

  • 25921037

Pubmed Central ID

  • PMC4463026

Electronic International Standard Serial Number (EISSN)

  • 1477-0970

Digital Object Identifier (DOI)

  • 10.1177/1352458515572406


  • eng

Conference Location

  • England