Are Lethal Alleles Too Abundant in Humans?

Published

Journal Article

Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation-selection balance.

Full Text

Duke Authors

Cited Authors

  • Ballinger, MA; Noor, MAF

Published Date

  • February 2018

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 87 - 89

PubMed ID

  • 29290402

Pubmed Central ID

  • 29290402

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2017.12.013

Language

  • eng