Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.
OBJECTIVE: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. PATIENTS AND METHODS: Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ≥grade 3 Common Terminology Criteria for Adverse Events (CTCAE) neuropathy in European and African Americans. Data were meta-analyzed with GW associations of CTCAE ≥grade 3 versus
Sucheston-Campbell, LE; Clay-Gilmour, AI; Barlow, WE; Budd, GT; Stram, DO; Haiman, CA; Sheng, X; Yan, L; Zirpoli, G; Yao, S; Jiang, C; Owzar, K; Hershman, D; Albain, KS; Hayes, DF; Moore, HC; Hobday, TJ; Stewart, JA; Rizvi, A; Isaacs, C; Salim, M; Gralow, JR; Hortobagyi, GN; Livingston, RB; Kroetz, DL; Ambrosone, CB
Volume / Issue
Start / End Page
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)