Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.
Publication
, Journal Article
Sucheston-Campbell, LE; Clay-Gilmour, AI; Barlow, WE; Budd, GT; Stram, DO; Haiman, CA; Sheng, X; Yan, L; Zirpoli, G; Yao, S; Jiang, C ...
Published in: Pharmacogenet Genomics
February 2018
OBJECTIVE: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. PATIENTS AND METHODS: Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ≥grade 3 Common Terminology Criteria for Adverse Events (CTCAE) neuropathy in European and African Americans. Data were meta-analyzed with GW associations of CTCAE ≥grade 3 versus
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Published In
Pharmacogenet Genomics
DOI
EISSN
1744-6880
Publication Date
February 2018
Volume
28
Issue
2
Start / End Page
49 / 55
Location
United States
Related Subject Headings
- White People
- Taxoids
- Polymorphism, Single Nucleotide
- Pharmacology & Pharmacy
- Peripheral Nervous System Diseases
- Humans
- Genotype
- Genomics
- Genome-Wide Association Study
- Genetic Predisposition to Disease
Citation
APA
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ICMJE
MLA
NLM
Sucheston-Campbell, L. E., Clay-Gilmour, A. I., Barlow, W. E., Budd, G. T., Stram, D. O., Haiman, C. A., … Ambrosone, C. B. (2018). Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Pharmacogenet Genomics, 28(2), 49–55. https://doi.org/10.1097/FPC.0000000000000318
Sucheston-Campbell, Lara E., Alyssa I. Clay-Gilmour, William E. Barlow, G Thomas Budd, Daniel O. Stram, Christopher A. Haiman, Xin Sheng, et al. “Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.” Pharmacogenet Genomics 28, no. 2 (February 2018): 49–55. https://doi.org/10.1097/FPC.0000000000000318.
Sucheston-Campbell LE, Clay-Gilmour AI, Barlow WE, Budd GT, Stram DO, Haiman CA, et al. Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Pharmacogenet Genomics. 2018 Feb;28(2):49–55.
Sucheston-Campbell, Lara E., et al. “Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.” Pharmacogenet Genomics, vol. 28, no. 2, Feb. 2018, pp. 49–55. Pubmed, doi:10.1097/FPC.0000000000000318.
Sucheston-Campbell LE, Clay-Gilmour AI, Barlow WE, Budd GT, Stram DO, Haiman CA, Sheng X, Yan L, Zirpoli G, Yao S, Jiang C, Owzar K, Hershman D, Albain KS, Hayes DF, Moore HC, Hobday TJ, Stewart JA, Rizvi A, Isaacs C, Salim M, Gralow JR, Hortobagyi GN, Livingston RB, Kroetz DL, Ambrosone CB. Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Pharmacogenet Genomics. 2018 Feb;28(2):49–55.
Published In
Pharmacogenet Genomics
DOI
EISSN
1744-6880
Publication Date
February 2018
Volume
28
Issue
2
Start / End Page
49 / 55
Location
United States
Related Subject Headings
- White People
- Taxoids
- Polymorphism, Single Nucleotide
- Pharmacology & Pharmacy
- Peripheral Nervous System Diseases
- Humans
- Genotype
- Genomics
- Genome-Wide Association Study
- Genetic Predisposition to Disease