Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature.

Published

Journal Article (Review)

PURPOSE: Gain-of-function mutations in the KCNT1 gene have been reported in a number of drug resistant epilepsy syndromes including Epilepsy of Infancy with Migrating Focal Seizures. Quinidine, a potassium channel blocker, has been proposed as a potential therapeutic agent with only a few patients reported in the literature to have received it. Here we report 3 additional children, with such KCNT1 mutations and refractory seizures, who received quinidine therapy. METHODS: Retrospective chart review of 3 children with KCNT1 mutations, of ages 3 months, 9 years and 13 years old. Video-EEG documented seizure type and frequency. Seizure frequency was compared before and after quinidine initiation. We then analyzed seizure response (defined as  > 50% reduction in seizure frequency) as it related to age in our 3 reported children, an additional 2 previously seen by us in our center, and an additional 3 reported in the literature (total 8 cases). RESULTS: In our report, the 3-month-old infant responded to quinidine, while the two older children did not. Using a cutoff of 4 years of age, review of the total of 8 cases, five from our center, revealed that all patients younger than 4 years responded to quinidine (4/4), while none of the ones older than 4 years did (0/4). CONCLUSION: The above-mentioned findings support performance of prospective controlled studies of quinidine efficacy in children with KCNT1 gain-of-function mutations that control for age as a possible variable affecting response.

Full Text

Duke Authors

Cited Authors

  • Abdelnour, E; Gallentine, W; McDonald, M; Sachdev, M; Jiang, Y-H; Mikati, MA

Published Date

  • February 2018

Published In

Volume / Issue

  • 55 /

Start / End Page

  • 1 - 3

PubMed ID

  • 29291456

Pubmed Central ID

  • 29291456

Electronic International Standard Serial Number (EISSN)

  • 1532-2688

Digital Object Identifier (DOI)

  • 10.1016/j.seizure.2017.11.017

Language

  • eng

Conference Location

  • England