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Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry.

Publication ,  Journal Article
Simmons, JH; Foster, NC; Riddlesworth, TD; DuBose, SN; Redondo, MJ; Liu, E; Freemark, M; T1D Exchange Clinic Network,
Published in: Pediatr Diabetes
June 2018

BACKGROUND: Celiac disease (CD) is common in patients with type 1 diabetes (T1D) and effects of CD on growth in children with T1D remain unclear. METHODS: We analyzed heights, weights, and body mass index (BMI) in 215 matched pediatric CD/control pairs in the T1D Exchange Clinic Registry. CD was defined by a clinic-reported diagnosis and positive celiac serology (n = 80) and/or positive small bowel biopsy (n = 135). Cases and controls were matched by age (mean: 14 years), diabetes duration (median: 7 years), sex (57% female), and clinic site. There were 5569 height/weight measurements. RESULTS: Gluten was restricted for varying periods of time in 61% of females and 51% of males with CD. Females with CD were shorter than female controls at all ages (P = 0.01). Weight z-scores were initially lower in preschool females with CD but similar to controls by middle childhood. Males with CD were initially shorter but adult heights were similar. Height in both sexes and weight in males were lower in CD participants diagnosed at younger age. Growth in T1D children with biopsy-proven CD, 76% of them were gluten-restricted, was comparable to that of T1D controls. CONCLUSION: Concurrent CD impairs linear growth in T1D females at all stages of development and in young T1D males. Young females with CD have lower weights, but both sexes have similar weights by middle childhood. Children younger at CD onset remain shorter throughout childhood; males younger at CD onset have persistently lower weights. Long-term gluten restriction may restore weight gain and linear growth in children with CD and T1D.

Duke Scholars

Published In

Pediatr Diabetes

DOI

EISSN

1399-5448

Publication Date

June 2018

Volume

19

Issue

4

Start / End Page

741 / 748

Location

Denmark

Related Subject Headings

  • Weight Gain
  • Sex Factors
  • Retrospective Studies
  • Registries
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 1
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Simmons, J. H., Foster, N. C., Riddlesworth, T. D., DuBose, S. N., Redondo, M. J., Liu, E., … T1D Exchange Clinic Network, . (2018). Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Pediatr Diabetes, 19(4), 741–748. https://doi.org/10.1111/pedi.12629
Simmons, Jill H., Nicole C. Foster, Tonya D. Riddlesworth, Stephanie N. DuBose, Maria J. Redondo, Edwin Liu, Michael Freemark, and Michael T1D Exchange Clinic Network. “Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry.Pediatr Diabetes 19, no. 4 (June 2018): 741–48. https://doi.org/10.1111/pedi.12629.
Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, et al. Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Pediatr Diabetes. 2018 Jun;19(4):741–8.
Simmons, Jill H., et al. “Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry.Pediatr Diabetes, vol. 19, no. 4, June 2018, pp. 741–48. Pubmed, doi:10.1111/pedi.12629.
Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, Freemark M, T1D Exchange Clinic Network. Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Pediatr Diabetes. 2018 Jun;19(4):741–748.
Journal cover image

Published In

Pediatr Diabetes

DOI

EISSN

1399-5448

Publication Date

June 2018

Volume

19

Issue

4

Start / End Page

741 / 748

Location

Denmark

Related Subject Headings

  • Weight Gain
  • Sex Factors
  • Retrospective Studies
  • Registries
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 1
  • Child, Preschool