Invading, Leading and Navigating Cells in Caenorhabditis elegans : Insights into Cell Movement in Vivo .
Journal Article (Review;Journal Article)
Highly regulated cell migration events are crucial during animal tissue formation and the trafficking of cells to sites of infection and injury. Misregulation of cell movement underlies numerous human diseases, including cancer. Although originally studied primarily in two-dimensional in vitro assays, most cell migrations in vivo occur in complex three-dimensional tissue environments that are difficult to recapitulate in cell culture or ex vivo Further, it is now known that cells can mobilize a diverse repertoire of migration modes and subcellular structures to move through and around tissues. This review provides an overview of three distinct cellular movement events in Caenorhabditis elegans -cell invasion through basement membrane, leader cell migration during organ formation, and individual cell migration around tissues-which together illustrate powerful experimental models of diverse modes of movement in vivo We discuss new insights into migration that are emerging from these in vivo studies and important future directions toward understanding the remarkable and assorted ways that cells move in animals.
Full Text
Duke Authors
Cited Authors
- Sherwood, DR; Plastino, J
Published Date
- January 2018
Published In
Volume / Issue
- 208 / 1
Start / End Page
- 53 - 78
PubMed ID
- 29301948
Pubmed Central ID
- PMC5753875
Electronic International Standard Serial Number (EISSN)
- 1943-2631
International Standard Serial Number (ISSN)
- 0016-6731
Digital Object Identifier (DOI)
- 10.1534/genetics.117.300082
Language
- eng