Sample size determination for jointly testing a cause-specific hazard and the all-cause hazard in the presence of competing risks.
Published
Journal Article
This article considers sample size determination for jointly testing a cause-specific hazard and the all-cause hazard for competing risks data. The cause-specific hazard and the all-cause hazard jointly characterize important study end points such as the disease-specific survival and overall survival, which are commonly used as coprimary end points in clinical trials. Specifically, we derive sample size calculation methods for 2-group comparisons based on an asymptotic chi-square joint test and a maximum joint test of the aforementioned quantities, taking into account censoring due to lost to follow-up as well as staggered entry and administrative censoring. We illustrate the application of the proposed methods using the Die Deutsche Diabetes Dialyse Studies clinical trial. An R package "powerCompRisk" has been developed and made available at the CRAN R library.
Full Text
Duke Authors
Cited Authors
- Yang, Q; Fung, WK; Li, G
Published Date
- April 2018
Published In
Volume / Issue
- 37 / 8
Start / End Page
- 1389 - 1401
PubMed ID
- 29282764
Pubmed Central ID
- 29282764
Electronic International Standard Serial Number (EISSN)
- 1097-0258
International Standard Serial Number (ISSN)
- 0277-6715
Digital Object Identifier (DOI)
- 10.1002/sim.7590
Language
- eng