Local control of melanoma brain metastases treated with stereotactic radiosurgery.


Journal Article

To examine the effectiveness of stereotactic radiosurgery (SRS) for melanoma brain metastases, as the optimal management is unknown.Patients with melanoma brain metastases treated between 1999 and 2013 with SRS as initial management were reviewed. Local control (LC), intracranial progression free survival, and overall survival were evaluated using the Kaplan Meier analysis and logistic regression.185 patients were identified with 435 treated brain metastases. 76% of metastases were controlled, with a median freedom from local failure of 23.4 months. Higher SRS dose (p=0.001) and smaller tumor volume (p=0.0007) were associated with improved LC on univariate analysis, but on multivariate analysis only smaller tumor volume remained significant (p=0.047). At analysis, 7.6% of patients were alive and the median time to death after SRS was 7.8 months.SRS is an effective primary treatment for melanoma brain metastases. There was no benefit combining SRS and surgery or whole brain radiotherapy.

Full Text

Duke Authors

Cited Authors

  • Bagshaw, HP; Ly, D; Suneja, G; Jensen, RL; Shrieve, DC

Published Date

  • January 2016

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 181 - 190

PubMed ID

  • 29296443

Pubmed Central ID

  • 29296443

Electronic International Standard Serial Number (EISSN)

  • 2156-4647

International Standard Serial Number (ISSN)

  • 2156-4639


  • eng