Bayesian inference and testing of group differences in brain networks

Published

Journal Article

© 2018 International Society for Bayesian Analysis. Network data are increasingly collected along with other variables of interest. Our motivation is drawn from neurophysiology studies measuring brain connectivity networks for a sample of individuals along with their membership to a low or high creative reasoning group. It is of paramount importance to develop statistical methods for testing of global and local changes in the structural interconnections among brain regions across groups. We develop a general Bayesian procedure for inference and testing of group differences in the network structure, which relies on a nonparametric representation for the conditional probability mass function associated with a network-valued random variable. By leveraging a mixture of low-rank factorizations, we allow simple global and local hypothesis testing adjusting for multiplicity. An efficient Gibbs sampler is defined for posterior computation. We provide theoretical results on the flexibility of the model and assess testing performance in simulations. The approach is applied to provide novel insights on the relationships between human brain networks and creativity.

Full Text

Duke Authors

Cited Authors

  • Durante, D; Dunson, DB

Published Date

  • January 1, 2018

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 29 - 58

Electronic International Standard Serial Number (EISSN)

  • 1931-6690

International Standard Serial Number (ISSN)

  • 1936-0975

Digital Object Identifier (DOI)

  • 10.1214/16-BA1030

Citation Source

  • Scopus