The protein binding of timegadine determined by equilibrium dialysis.

Published

Journal Article

The protein binding of timegadine to albumin, serum, plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein, alpha 1-anti-trypsin and C-reactive protein was determined by equilibrium dialysis. The effects of other analgesic and anti-inflammatories (indomethacin, ketoprofen, paracetamol and sodium salicylate) and other basic drugs (disopyramide, lignocaine, propranolol and quinidine) on the binding of timegadine were also determined. Timegadine binding was concentration-dependent up to 0.5 micrograms/ml, but independent above this level up to 10.0 micrograms/ml, the mean and standard error being 93.8 +/- 0.5%. Albumin accounted for only 32.4% of timegadine bound to plasma. Plasma enrichment with the acute phase reactants led to significant increases in timegadine binding. Simultaneous dialysis with other drugs caused significant decreases in timegadine binding.

Full Text

Duke Authors

Cited Authors

  • George, S; McBurney, A; Ward, J

Published Date

  • November 1, 1984

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 785 - 790

PubMed ID

  • 6508987

Pubmed Central ID

  • 6508987

International Standard Serial Number (ISSN)

  • 0306-5251

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2125.1984.tb02543.x

Language

  • eng

Conference Location

  • England