Possible protein binding displacement interaction between glibenclamide and metolazone.
Publication
, Journal Article
George, S; McBurney, A; Cole, A
Published in: Eur J Clin Pharmacol
1990
The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
Duke Scholars
Published In
Eur J Clin Pharmacol
DOI
ISSN
0031-6970
Publication Date
1990
Volume
38
Issue
1
Start / End Page
93 / 95
Location
Germany
Related Subject Headings
- Protein Binding
- Pharmacology & Pharmacy
- Metolazone
- Male
- Hydrogen-Ion Concentration
- Humans
- Heart Failure
- Glyburide
- Diuretics
- Dialysis
Citation
APA
Chicago
ICMJE
MLA
NLM
George, S., McBurney, A., & Cole, A. (1990). Possible protein binding displacement interaction between glibenclamide and metolazone. Eur J Clin Pharmacol, 38(1), 93–95. https://doi.org/10.1007/BF00314813
George, S., A. McBurney, and A. Cole. “Possible protein binding displacement interaction between glibenclamide and metolazone.” Eur J Clin Pharmacol 38, no. 1 (1990): 93–95. https://doi.org/10.1007/BF00314813.
George S, McBurney A, Cole A. Possible protein binding displacement interaction between glibenclamide and metolazone. Eur J Clin Pharmacol. 1990;38(1):93–5.
George, S., et al. “Possible protein binding displacement interaction between glibenclamide and metolazone.” Eur J Clin Pharmacol, vol. 38, no. 1, 1990, pp. 93–95. Pubmed, doi:10.1007/BF00314813.
George S, McBurney A, Cole A. Possible protein binding displacement interaction between glibenclamide and metolazone. Eur J Clin Pharmacol. 1990;38(1):93–95.
Published In
Eur J Clin Pharmacol
DOI
ISSN
0031-6970
Publication Date
1990
Volume
38
Issue
1
Start / End Page
93 / 95
Location
Germany
Related Subject Headings
- Protein Binding
- Pharmacology & Pharmacy
- Metolazone
- Male
- Hydrogen-Ion Concentration
- Humans
- Heart Failure
- Glyburide
- Diuretics
- Dialysis