Possible protein binding displacement interaction between glibenclamide and metolazone.

Journal Article (Journal Article)

The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.

Full Text

Duke Authors

Cited Authors

  • George, S; McBurney, A; Cole, A

Published Date

  • 1990

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 93 - 95

PubMed ID

  • 2109700

International Standard Serial Number (ISSN)

  • 0031-6970

Digital Object Identifier (DOI)

  • 10.1007/BF00314813


  • eng

Conference Location

  • Germany