Induced basal normoglycemia and altered platelet aggregation in non-insulin-dependent diabetes.

Journal Article (Journal Article)

Non-insulin-dependent diabetic subjects had abnormally raised in vitro platelet aggregation rates to collagen or ristocetin when thought to be "well-controlled" on diet alone but shown to have raised basal plasma glucose levels. Basal normoglycemia, induced with either ultralente insulin or chlorpropamide, was associated with a significant reduction of the enhanced platelet aggregation rates to normal. Some sulfonylurea drugs have been reported to have specific anti-platelet aggregatory properties, but the degree of plasma glucose control is probably more relevant.

Full Text

Duke Authors

Cited Authors

  • Evans, RJ; Lane, J; Holman, RR; Turner, RC

Published Date

  • July 1982

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 433 - 437

PubMed ID

  • 6818012

International Standard Serial Number (ISSN)

  • 0149-5992

Digital Object Identifier (DOI)

  • 10.2337/diacare.5.4.433


  • eng

Conference Location

  • United States