A Novel 18 F-Labeling Method for the Synthesis of [ 18 F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors

Published

Journal Article

© Georg Thieme Verlag Stuttgart. We report a novel 18 F-labeling method for the preparation of 18 F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18 F-labeled potential PET radiotracers of σ receptors for initial biological evaluations. 1 Introduction 2 Design and Synthesis of Novel [ 19 F]-3 and [ 19 F]-3′ 3 Radiosynthesis of Novel [ 18 F]-3 and [ 18 F]-3′ 4 In vivo Uptake and Pharmacokinetics of [ 18 F]-3 and [ 18 F]-3′ 5 Conclusion.

Full Text

Duke Authors

Cited Authors

  • Ortiz, GX; Chansaenpak, K; Wang, M; Ma, X; Wang, H; Li, Z; Wang, Q

Published Date

  • March 1, 2018

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 410 - 414

Electronic International Standard Serial Number (EISSN)

  • 1437-2096

International Standard Serial Number (ISSN)

  • 0936-5214

Digital Object Identifier (DOI)

  • 10.1055/s-0036-1591734

Citation Source

  • Scopus