Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.

Published

Journal Article

INTRODUCTION:This meta-analysis aims to examine whether the genotype status of Msp1, Ile462Val, and Thr461Asn polymorphisms in cytochrome P450 1A1 (CYP1A1) is associated with endometrial cancer risk. METHODS:Eligible case-control studies were identified through search in MEDLINE (end of search: August 2010). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. RESULTS:Concerning MspI polymorphism, 8 studies were eligible (1456 cases and 2371 controls); 9 studies were eligible (1889 cases and 3662 controls) for Ile462Val and 6 studies were eligible (1272 cases and 2122 controls) for Thr461Asn. MspI polymorphism was not associated with endometrial cancer risk (for heterozygous TC vs TT carriers: OR = 0.83, 95% confidence interval [CI], 0.59-1.15, random effects; for homozygous CC vs TT carriers: OR = 1.00, 95% CI, 0.55-1.82, fixed effects). Similarly, Ile462Val polymorphism was not associated with endometrial cancer risk (for heterozygous Ile/Val vs Ile/Ile carriers: OR = 1.27, 95% CI, 0.78-2.06, random effects; for homozygous Val/Val vs Ile/Ile carriers: OR = 1.16, 95% CI, 0.48-2.81, fixed effects). Accordingly, Thr461Asn status was not significantly associated with endometrial cancer risk. The same results were reproduced in Caucasians. CONCLUSIONS:The 3 examined CYP1A1 genotype polymorphisms do not seem to confer any additional risk for endometrial cancer in Caucasians. Accumulation of further data seems mandatory for future race-specific analyses.

Full Text

Duke Authors

Cited Authors

  • Sergentanis, TN; Economopoulos, KP; Choussein, S; Vlahos, NF

Published Date

  • February 2011

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 323 - 331

PubMed ID

  • 21270613

Pubmed Central ID

  • 21270613

Electronic International Standard Serial Number (EISSN)

  • 1525-1438

International Standard Serial Number (ISSN)

  • 1048-891X

Digital Object Identifier (DOI)

  • 10.1097/igc.0b013e31820575c0

Language

  • eng