Fertility drugs and ovarian cancer risk: a critical review of the literature.


Conference Paper

There is evidence that medications used for ovarian stimulation and in vitro fertilization may be associated with ovarian cancer. In this review, we attempt to describe this relationship according to the most recent epidemiologic data and to present the possible mechanisms on the molecular level that could potentially explain this correlation. Currently there is no proven relationship between any type of ovarian cancer and drugs used for infertility treatment. Overall, infertile women have increased risk for ovarian malignancies. Nulligravidas that received treatment are at increased risk for ovarian malignancy as compared to women that conceived after treatment. More studies with the appropriate statistical power and follow-up time, as well as with better adjustment for confounding factors, which coexist in infertile patients, are required to evaluate accurately the long-term effects of these drugs and procedures.

Full Text

Duke Authors

Cited Authors

  • Vlahos, NF; Economopoulos, KP; Creatsas, G

Published Date

  • September 2010

Published In

Volume / Issue

  • 1205 /

Start / End Page

  • 214 - 219

PubMed ID

  • 20840275

Pubmed Central ID

  • 20840275

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2010.05668.x