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Stem Cell Therapy for Congenital Heart Disease: A Systematic Review.

Publication ,  Journal Article
Tsilimigras, DI; Oikonomou, EK; Moris, D; Schizas, D; Economopoulos, KP; Mylonas, KS
Published in: Circulation
December 2017

Congenital heart disease (CHD) constitutes the most prevalent and heterogeneous group of congenital anomalies. Although surgery remains the gold standard treatment modality, stem cell therapy has been gaining ground as a complimentary or alternative treatment option in certain types of CHD. The aim of this study was to present the existing published evidence and ongoing research efforts on the implementation of stem cell-based therapeutic strategies in CHD.A systematic review was conducted by searching Medline, ClinicalTrials.gov, and the Cochrane library, along with reference lists of the included studies through April 23, 2017.Nineteen studies were included in this review (8 preclinical, 6 clinical, and 5 ongoing trials). Various routes of cardiac stem cell delivery have been reported, including intracoronary, intramyocardial, intravenous, and epicardial. Depending on their origin and level of differentiation at which they are harvested, stem cells may exhibit different properties. Preclinical studies have mostly focused on modeling right ventricle dysfunction or failure and pulmonary artery hypertension by using pressure or volume overload in vitro or in vivo. Only a limited number of clinical trials on patients with CHD exist, and these primarily focus on hypoplastic left heart syndrome. Cell-based tissue engineering has recently been introduced, and research currently is focusing on developing cell-seeded grafts and patches that could potentially grow in parallel with whole body growth once implanted in the heart.It seems that stem cell delivery to the diseased heart as an adjunct to surgical palliation may provide some benefits over surgery alone in terms of cardiac function, somatic growth, and quality of life. Despite encouraging preliminary results, stem cell therapies for patients with CHD should only be considered in the setting of well-designed clinical trials. More wet laboratory research experience is needed, and translation of promising findings to large clinical studies is warranted to clearly define the efficacy and safety profile of this alternative and potentially groundbreaking therapeutic approach.

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Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

December 2017

Volume

136

Issue

24

Start / End Page

2373 / 2385

Related Subject Headings

  • Tissue Engineering
  • Stem Cell Transplantation
  • Quality of Life
  • Hypoplastic Left Heart Syndrome
  • Humans
  • Heart Defects, Congenital
  • Guided Tissue Regeneration
  • Clinical Trials as Topic
  • Cell Differentiation
  • Cardiovascular System & Hematology
 

Citation

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Tsilimigras, D. I., Oikonomou, E. K., Moris, D., Schizas, D., Economopoulos, K. P., & Mylonas, K. S. (2017). Stem Cell Therapy for Congenital Heart Disease: A Systematic Review. Circulation, 136(24), 2373–2385. https://doi.org/10.1161/circulationaha.117.029607
Tsilimigras, Diamantis I., Evangelos K. Oikonomou, Demetrios Moris, Dimitrios Schizas, Konstantinos P. Economopoulos, and Konstantinos S. Mylonas. “Stem Cell Therapy for Congenital Heart Disease: A Systematic Review.Circulation 136, no. 24 (December 2017): 2373–85. https://doi.org/10.1161/circulationaha.117.029607.
Tsilimigras DI, Oikonomou EK, Moris D, Schizas D, Economopoulos KP, Mylonas KS. Stem Cell Therapy for Congenital Heart Disease: A Systematic Review. Circulation. 2017 Dec;136(24):2373–85.
Tsilimigras, Diamantis I., et al. “Stem Cell Therapy for Congenital Heart Disease: A Systematic Review.Circulation, vol. 136, no. 24, Dec. 2017, pp. 2373–85. Epmc, doi:10.1161/circulationaha.117.029607.
Tsilimigras DI, Oikonomou EK, Moris D, Schizas D, Economopoulos KP, Mylonas KS. Stem Cell Therapy for Congenital Heart Disease: A Systematic Review. Circulation. 2017 Dec;136(24):2373–2385.

Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

December 2017

Volume

136

Issue

24

Start / End Page

2373 / 2385

Related Subject Headings

  • Tissue Engineering
  • Stem Cell Transplantation
  • Quality of Life
  • Hypoplastic Left Heart Syndrome
  • Humans
  • Heart Defects, Congenital
  • Guided Tissue Regeneration
  • Clinical Trials as Topic
  • Cell Differentiation
  • Cardiovascular System & Hematology