Laparoscopic cholecystectomy during pregnancy: A systematic review of 590 patients.

Journal Article (Systematic Review;Review;Journal Article)


The incidence of symptomatic biliary disease during pregnancy ranges from 0.05 to 8%. Cholecystectomy is one of the common operations performed during pregnancy and laparoscopic approach has gained popularity as an attractive alternative to open surgery.


In order to evaluate the safety, feasibility, outcomes and technical aspects of laparoscopic cholecystectomy during pregnancy a comprehensive search of Medline and Cohrane Library databases was conducted.


Fifty-one studies were deemed eligible, in which laparoscopic cholecystectomy was attempted in 590 patients. The majority of the procedures (70.7%) were performed during the second trimester. Intraoperative and postoperative complications were observed in 3.5% and 4% of the study population. Conversion rate to open surgery was 2.2%. Fetal loss rate and preterm delivery rate were 0.4% and 5.7% respectively.


Laparoscopic cholecystectomy seems to be a safe alternative to open surgery during pregnancy.

Full Text

Duke Authors

Cited Authors

  • Nasioudis, D; Tsilimigras, D; Economopoulos, KP

Published Date

  • March 2016

Published In

Volume / Issue

  • 27 /

Start / End Page

  • 165 - 175

PubMed ID

  • 26826612

Electronic International Standard Serial Number (EISSN)

  • 1743-9159

International Standard Serial Number (ISSN)

  • 1743-9191

Digital Object Identifier (DOI)

  • 10.1016/j.ijsu.2016.01.070


  • eng