Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases


Conference Paper

The TWIST platform is an optical evanescent wave sensor which enables a label-free immunoassay-based portable instrument. The approach is based on input grating coupler sensors serving as functionalized sensing devices. Binding of the target analyte to the receptor-coated grating is detected by wavelength interrogation in the telecom spectral range. We have demonstrated that high performance volumetric sensing can be achieved using a compact, low-cost telecom laser as light source. The system footprint including light source, detectors and digitizers is compact. The platform is amenable to multiplexed operation. We demonstrated a two-output system which enables detection of an analyte with an on-chip reference signal. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Full Text

Duke Authors

Cited Authors

  • Grego, S; Gilchrist, KH; Stoner, BR

Published Date

  • July 6, 2011

Published In

Volume / Issue

  • 8029 /

International Standard Serial Number (ISSN)

  • 0277-786X

International Standard Book Number 13 (ISBN-13)

  • 9780819486035

Digital Object Identifier (DOI)

  • 10.1117/12.886880

Citation Source

  • Scopus