A compact and multichannel optical biosensor based on a wavelength interrogated input grating coupler

Journal Article (Journal Article)

The design, fabrication and characterization of a compact optical biosensor based on an input grating coupler are presented. The sensor device consists of a waveguide-integrated single grating structure. The optical reader is based on the use of a largely tunable, small footprint infrared laser for wavelength interrogation of the sensor and on edge-detection of waveguided modes, resulting in a compact configuration. A multiplexing approach is illustrated and a two-output sensor system is demonstrated. The device is packaged in a microfluidic cartridge for sample handling. The volumetric sensing performance of the system is characterized and a limit of detection of 1 × 10 -5 RIU is reported while the surface sensing capability is demonstrated by detection of protein diluted down to 200 ng/ml. © 2011 Elsevier B.V. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Grego, S; Gilchrist, KH; Carlson, JB; Stoner, BR

Published Date

  • January 3, 2012

Published In

Volume / Issue

  • 161 / 1

Start / End Page

  • 721 - 727

International Standard Serial Number (ISSN)

  • 0925-4005

Digital Object Identifier (DOI)

  • 10.1016/j.snb.2011.11.020

Citation Source

  • Scopus