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Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas.

Publication ,  Journal Article
Chłopik, A; Selim, MA; Peng, Y; Wu, C-L; Tell-Marti, G; Paral, KM; Shalin, SC; Kraft, S; Hsu, C-K; Shea, CR; Puig, S; Fernandez-Figueras, M-T ...
Published in: Hum Pathol
March 2018

The prognostic role of PDL1 expression, CD8+ and FoxP3+ lymphocytes in vulvar melanomas has not been studied. We correlated PDL1 expression and CD8+ and FoxP3+ immune infiltrates with clinicopathologic variables and patient outcomes in a series of 75 vulvar melanomas. Tumoral PDL1 expression (>5%) was seen in 23% of cases. By Fisher exact test, PDL1 expression and peritumoral FoxP3+ lymphocytes significantly correlated with less disease-specific death. By linear regression analysis, correlations between tumoral PDL1 expression with the density of tumoral CD8+ and peritumoral CD8+ lymphocytes, tumoral FoxP3+ with tumoral CD8+ lymphocytes, and peritumoral FoxP3+ with peritumoral CD8+ lymphocytes were observed. By univariate analyses, tumor thickness >4 mm predicted poorer progression-free survival, melanoma-specific survival, and overall survival. PDL1 expression >5% and peritumoral CD8+, peritumoral FoxP3+, and tumoral FoxP3+ lymphocytes correlated with better overall survival. By multivariate analyses, high peritumoral FoxP3+ lymphocytes independently predicted better melanoma-specific survival (P = .023), and tumor thickness independently predicted poorer progression-free survival (P = .05) and overall survival (P = .039). In conclusion, our study shows that, independent from tumor thickness, an increased density of peritumoral FoxP3+ lymphocytes may positively impact survival in a subset of vulvar melanomas. Tumoral PDL1 expression correlated with tumoral as well as peritumoral CD8+ and FoxP3+ lymphocytes, supportive of an adaptive immune response. Although the frequency of PDL1 expression is low in vulvar melanoma, its expression may identify a subset of vulvar melanoma that might respond to immunotherapy.

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Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

March 2018

Volume

73

Start / End Page

176 / 183

Location

United States

Related Subject Headings

  • Young Adult
  • Vulvar Neoplasms
  • T-Lymphocytes, Regulatory
  • Progression-Free Survival
  • Prognosis
  • Pathology
  • Middle Aged
  • Melanoma
  • Lymphocytes, Tumor-Infiltrating
  • Kaplan-Meier Estimate
 

Citation

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ICMJE
MLA
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Chłopik, A., Selim, M. A., Peng, Y., Wu, C.-L., Tell-Marti, G., Paral, K. M., … Hoang, M. P. (2018). Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas. Hum Pathol, 73, 176–183. https://doi.org/10.1016/j.humpath.2017.12.022
Chłopik, Agata, M Angelica Selim, Yan Peng, Cheng-Lin Wu, Gemma Tell-Marti, Kristen M. Paral, Sara C. Shalin, et al. “Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas.Hum Pathol 73 (March 2018): 176–83. https://doi.org/10.1016/j.humpath.2017.12.022.
Chłopik A, Selim MA, Peng Y, Wu C-L, Tell-Marti G, Paral KM, et al. Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas. Hum Pathol. 2018 Mar;73:176–83.
Chłopik, Agata, et al. “Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas.Hum Pathol, vol. 73, Mar. 2018, pp. 176–83. Pubmed, doi:10.1016/j.humpath.2017.12.022.
Chłopik A, Selim MA, Peng Y, Wu C-L, Tell-Marti G, Paral KM, Shalin SC, Kraft S, Hsu C-K, Shea CR, Puig S, Fernandez-Figueras M-T, Biernat W, Ryś J, Marszalek A, Hoang MP. Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas. Hum Pathol. 2018 Mar;73:176–183.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

March 2018

Volume

73

Start / End Page

176 / 183

Location

United States

Related Subject Headings

  • Young Adult
  • Vulvar Neoplasms
  • T-Lymphocytes, Regulatory
  • Progression-Free Survival
  • Prognosis
  • Pathology
  • Middle Aged
  • Melanoma
  • Lymphocytes, Tumor-Infiltrating
  • Kaplan-Meier Estimate