Isolated Central Nervous System Chloroma as a Presenting Sign of Relapsed Pediatric Acute Lymphoblastic Leukemia.
Journal Article (Journal Article)
Central nervous system (CNS) chloromas are an exceedingly rare presentation of CNS relapse in acute lymphoblastic leukemia (ALL). We report a relapsed ALL patient who presented with 2 separate chloromas and cerebrospinal fluid lymphoblastocytosis, and outline a treatment plan of systemic chemotherapy and CNS-directed radiation therapy. A review of the literature indicates that multiagent chemotherapy combined with CNS radiotherapy is effective, with hematopoietic stem cell transplantation used in half of reported cases. We conclude that intensive systemic multiagent chemotherapy with CNS-directed radiation therapy can be successfully used to treat relapsed pediatric ALL with CNS lymphoblastic chloroma.
Full Text
Duke Authors
Cited Authors
- Heath, JL; Aumann, WK; Maxfield, CM; Wechsler, DS
Published Date
- October 2018
Published In
Volume / Issue
- 40 / 7
Start / End Page
- e442 - e445
PubMed ID
- 29334537
Electronic International Standard Serial Number (EISSN)
- 1536-3678
Digital Object Identifier (DOI)
- 10.1097/MPH.0000000000001085
Language
- eng
Conference Location
- United States