Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange.

Journal Article (Journal Article)

A systematic experimental study is reported on the polarization transfer to distant spins, which do not directly bind to the polarization transfer complexes employed in Signal Amplification By Reversible Exchange (SABRE) experiments. Both, long-range transfer to protons and long-range transfer to heteronuclei i.e. 13 C and 15 N are examined. Selective destruction of hyperpolarization on 1 H, 13 C, and 15 N sites is employed, followed by their re-hyperpolarization from neighboring spins within the molecules of interest (pyridine for 1 H studies and metronidazole-15 N2 -13 C2 for 13 C and 15 N studies). We conclude that long-range sites can be efficiently hyperpolarized when a network of spin-½ nuclei enables relayed polarization transfer (i.e . via short-range interactions between sites). In case of proton SABRE in the milli-Tesla regime, a relay network consisting of protons only is sufficient. However, in case 13 C and 15 N are targeted (i.e. via SABRE in SHield Enables Alignment Transfer to Heteronuclei or SABRE-SHEATH experiment), the presence of a heteronuclear network (e.g . consisting of 15 N) enables a relay mechanism that is significantly more efficient than the direct transfer of spin order from para -H2 -derived hydrides.

Full Text

Duke Authors

Cited Authors

  • Shchepin, RV; Jaigirdar, L; Theis, T; Warren, WS; Goodson, BM; Chekmenev, EY

Published Date

  • December 2017

Published In

Volume / Issue

  • 121 / 51

Start / End Page

  • 28425 - 28434

PubMed ID

  • 29955243

Pubmed Central ID

  • PMC6017995

Electronic International Standard Serial Number (EISSN)

  • 1932-7455

International Standard Serial Number (ISSN)

  • 1932-7447

Digital Object Identifier (DOI)

  • 10.1021/acs.jpcc.7b11485


  • eng