A systematic experimental study is reported on the polarization transfer to distant spins, which do not directly bind to the polarization transfer complexes employed in Signal Amplification By Reversible Exchange (SABRE) experiments. Both, long-range transfer to protons and long-range transfer to heteronuclei i.e. ¹³ C and ¹⁵ N are examined. Selective destruction of hyperpolarization on ¹ H, ¹³ C, and ¹⁵ N sites is employed, followed by their re-hyperpolarization from neighboring spins within the molecules of interest (pyridine for ¹ H studies and metronidazole-¹⁵ N₂ -¹³ C₂ for ¹³ C and ¹⁵ N studies). We conclude that long-range sites can be efficiently hyperpolarized when a network of spin-½ nuclei enables relayed polarization transfer (i.e . via short-range interactions between sites). In case of proton SABRE in the milli-Tesla regime, a relay network consisting of protons only is sufficient. However, in case ¹³ C and ¹⁵ N are targeted (i.e. via SABRE in SHield Enables Alignment Transfer to Heteronuclei or SABRE-SHEATH experiment), the presence of a heteronuclear network (e.g . consisting of ¹⁵ N) enables a relay mechanism that is significantly more efficient than the direct transfer of spin order from para -H₂ -derived hydrides.