Metabolic Barriers to T Cell Function in Tumors.

Journal Article (Journal Article;Review)

The metabolic programs that drive T cell functions are exquisitely sensitive to cell intrinsic and extrinsic factors, allowing T cells to respond in a fine-tuned manner to a variety of immune challenges and conditions. However, many of the factors essential for effector T cell function are perturbed in the tumor microenvironment, where oncogenic mutations drive unrestrained cancer cell growth that leads to excess nutrient consumption, excess waste excretion, and insufficient oxygen delivery. This imposes metabolic constraints on infiltrating cells that result in dysfunction and loss of potential antitumor activity in both naturally occurring as well as tailored T cells introduced as part of immunotherapy. In this review, we highlight the metabolic properties that characterize tumor-infiltrating T cells, the barriers within the metabolic landscape of the tumor microenvironment, and the opportunities and challenges they present in development of new cancer therapeutics.

Full Text

Duke Authors

Cited Authors

  • Sugiura, A; Rathmell, JC

Published Date

  • January 15, 2018

Published In

Volume / Issue

  • 200 / 2

Start / End Page

  • 400 - 407

PubMed ID

  • 29311381

Pubmed Central ID

  • PMC5777533

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1701041


  • eng

Conference Location

  • United States