A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine.

Journal Article (Journal Article;Review)

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a critical post-translational modification (PTM) of thousands of intracellular proteins. Reversible O-GlcNAcylation governs many aspects of cell physiology and is dysregulated in numerous human diseases. Despite this broad pathophysiological significance, major aspects of O-GlcNAc signaling remain poorly understood, including the biochemical mechanisms through which O-GlcNAc transduces information. Recent work from many laboratories, including our own, has revealed that O-GlcNAc, like other intracellular PTMs, can control its substrates' functions by inhibiting or inducing protein-protein interactions. This dynamic regulation of multiprotein complexes exerts diverse downstream signaling effects in a range of processes, cell types, and organisms. Here, we review the literature about O-GlcNAc-regulated protein-protein interactions and suggest important questions for future studies in the field.

Full Text

Duke Authors

Cited Authors

  • Tarbet, HJ; Toleman, CA; Boyce, M

Published Date

  • January 9, 2018

Published In

Volume / Issue

  • 57 / 1

Start / End Page

  • 13 - 21

PubMed ID

  • 29099585

Pubmed Central ID

  • PMC5807727

Electronic International Standard Serial Number (EISSN)

  • 1520-4995

Digital Object Identifier (DOI)

  • 10.1021/acs.biochem.7b00871


  • eng

Conference Location

  • United States