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Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.

Publication ,  Journal Article
Li, JY; Middleton, DM; Chen, S; White, L; Corado, CR; Vite, C; Bradbury, A; Provenzale, JM
Published in: Neuroradiol J
April 2018

Purpose The purpose of this study was to compare quantitative diffusion tensor imaging metrics in dogs affected with a model of Krabbe disease to age-matched normal controls. We hypothesized that fractional anisotropy would be decreased and radial diffusivity would be increased in the Krabbe dogs. Methods We used a highly reproducible region-of-interest interrogation technique to measure fractional anisotropy and radial diffusivity in three different white matter regions within the internal capsule and centrum semiovale in four Krabbe affected brains and three age-matched normal control brains. Results Despite all four Krabbe dogs manifesting pelvic limb paralysis at the time of death, age-dependent differences in DTI metrics were observed. In the 9, 12, and 14 week old Krabbe dogs, FA values unexpectedly increased and RD values decreased. FA values were generally higher and RD values generally lower in both regions of the internal capsule in the Krabbe brains during this period. FA values in the brain from the 16 week old Krabbe dog decreased and were lower than in control brains and RD values increased and were higher than in control brain. Conclusion Our findings suggest that FA and RD in the internal capsule and centrum semiovale are affected differently at different ages, despite disease having progressed to pelvic limb paralysis in all dogs evaluated. In 9, 12, and 14 week old Krabbe dogs, higher FA values and lower RD values are seen in the internal capsule. However, in the 16 week old Krabbe dog, lower FA and higher RD values are seen, consistent with previous observations in Krabbe dogs, as well as observations in human Krabbe patients.

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Published In

Neuroradiol J

DOI

EISSN

2385-1996

Publication Date

April 2018

Volume

31

Issue

2

Start / End Page

168 / 176

Location

United States

Related Subject Headings

  • White Matter
  • Nuclear Medicine & Medical Imaging
  • Leukodystrophy, Globoid Cell
  • Dogs
  • Disease Models, Animal
  • Diffusion Tensor Imaging
  • Anisotropy
  • Animals
  • Age Factors
  • 3209 Neurosciences
 

Citation

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Li, J. Y., Middleton, D. M., Chen, S., White, L., Corado, C. R., Vite, C., … Provenzale, J. M. (2018). Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages. Neuroradiol J, 31(2), 168–176. https://doi.org/10.1177/1971400917733431
Li, Jonathan Y., Dana M. Middleton, Steven Chen, Leonard White, Carley R. Corado, Charles Vite, Allison Bradbury, and James M. Provenzale. “Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.Neuroradiol J 31, no. 2 (April 2018): 168–76. https://doi.org/10.1177/1971400917733431.
Li JY, Middleton DM, Chen S, White L, Corado CR, Vite C, et al. Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages. Neuroradiol J. 2018 Apr;31(2):168–76.
Li, Jonathan Y., et al. “Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.Neuroradiol J, vol. 31, no. 2, Apr. 2018, pp. 168–76. Pubmed, doi:10.1177/1971400917733431.
Li JY, Middleton DM, Chen S, White L, Corado CR, Vite C, Bradbury A, Provenzale JM. Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages. Neuroradiol J. 2018 Apr;31(2):168–176.
Journal cover image

Published In

Neuroradiol J

DOI

EISSN

2385-1996

Publication Date

April 2018

Volume

31

Issue

2

Start / End Page

168 / 176

Location

United States

Related Subject Headings

  • White Matter
  • Nuclear Medicine & Medical Imaging
  • Leukodystrophy, Globoid Cell
  • Dogs
  • Disease Models, Animal
  • Diffusion Tensor Imaging
  • Anisotropy
  • Animals
  • Age Factors
  • 3209 Neurosciences