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Intraoperative radiation therapy for high-risk pediatric neuroblastoma.

Publication ,  Journal Article
Haas-Kogan, DA; Fisch, BM; Wara, WM; Swift, PS; Farmer, DL; Harrison, MR; Albanese, C; Weinberg, V; Matthay, KK
Published in: International journal of radiation oncology, biology, physics
July 2000

To evaluate the efficacy of intraoperative radiation therapy (IORT) in the treatment of high-risk pediatric neuroblastoma.Between 1986 and 1998, 23 children received IORT for pediatric neuroblastoma. Electron beam energies ranged from 4 MeV to 16 MeV and median dose was 10 Gy (7-16 Gy).Twenty-one of 23 patients were classified as high-risk. A gross total resection (GTR) was achieved in 18 patients, of whom 6 experienced disease recurrence, 2 of which included a locoregional relapse as a component of failure. Fourteen of 18 patients receiving IORT after a GTR are disease-free survivors. A second subset of 5 patients had a subtotal resection (STR), with gross residual disease remaining after surgery. All 5 patients recurred locally, and all died of their disease. IORT was extremely well-tolerated in our cohort. Surgical resection and IORT resulted in the narrowing of the abdominal aorta and an atrophic kidney in 1 patient.For high-risk neuroblastoma patients, IORT as the only radiotherapy to the primary, produced excellent local control after a GTR. However, IORT as the sole radiotherapy to the primary was inadequate for patients with extensive adenopathy or an STR. In this setting, we are exploring the use of IORT as a boost in conjunction with external beam radiation therapy.

Published In

International journal of radiation oncology, biology, physics

DOI

EISSN

1879-355X

ISSN

0360-3016

Publication Date

July 2000

Volume

47

Issue

4

Start / End Page

985 / 992

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Survival Analysis
  • Retroperitoneal Neoplasms
  • Remission Induction
  • Radiotherapy, Adjuvant
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
 

Citation

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Haas-Kogan, D. A., Fisch, B. M., Wara, W. M., Swift, P. S., Farmer, D. L., Harrison, M. R., … Matthay, K. K. (2000). Intraoperative radiation therapy for high-risk pediatric neuroblastoma. International Journal of Radiation Oncology, Biology, Physics, 47(4), 985–992. https://doi.org/10.1016/s0360-3016(00)00432-6
Haas-Kogan, D. A., B. M. Fisch, W. M. Wara, P. S. Swift, D. L. Farmer, M. R. Harrison, C. Albanese, V. Weinberg, and K. K. Matthay. “Intraoperative radiation therapy for high-risk pediatric neuroblastoma.International Journal of Radiation Oncology, Biology, Physics 47, no. 4 (July 2000): 985–92. https://doi.org/10.1016/s0360-3016(00)00432-6.
Haas-Kogan DA, Fisch BM, Wara WM, Swift PS, Farmer DL, Harrison MR, et al. Intraoperative radiation therapy for high-risk pediatric neuroblastoma. International journal of radiation oncology, biology, physics. 2000 Jul;47(4):985–92.
Haas-Kogan, D. A., et al. “Intraoperative radiation therapy for high-risk pediatric neuroblastoma.International Journal of Radiation Oncology, Biology, Physics, vol. 47, no. 4, July 2000, pp. 985–92. Epmc, doi:10.1016/s0360-3016(00)00432-6.
Haas-Kogan DA, Fisch BM, Wara WM, Swift PS, Farmer DL, Harrison MR, Albanese C, Weinberg V, Matthay KK. Intraoperative radiation therapy for high-risk pediatric neuroblastoma. International journal of radiation oncology, biology, physics. 2000 Jul;47(4):985–992.
Journal cover image

Published In

International journal of radiation oncology, biology, physics

DOI

EISSN

1879-355X

ISSN

0360-3016

Publication Date

July 2000

Volume

47

Issue

4

Start / End Page

985 / 992

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Survival Analysis
  • Retroperitoneal Neoplasms
  • Remission Induction
  • Radiotherapy, Adjuvant
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Neoplasm Staging
  • Neoplasm Recurrence, Local