Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras.


Journal Article

Transplantation of normal, immature, fetal hematopoietic cells into a preimmune fetal recipient with a congenital hemoglobinopathy may allow partial reconstitution of normal hemoglobin production without the complications associated with postnatal bone marrow transplantation (immunosuppression and the occurrence of graft versus host disease). In order to test this hypothesis the naturally occurring polymorphism at the beta-hemoglobin locus of the sheep was used as a marker for engraftment and hematopoietic chimerism. Intraperitoneal injection of allogeneic fetal stem cells into normal fetal lambs resulted in hematopoietic chimerism in three of four surviving recipients. This chimerism has been sustained for 6 months after birth and 9 months after engraftment, without evidence of graft versus host disease, and without the use of immunosuppressive therapy.

Full Text

Cited Authors

  • Flake, AW; Harrison, MR; Adzick, NS; Zanjani, ED

Published Date

  • August 1, 1986

Published In

Volume / Issue

  • 233 / 4765

Start / End Page

  • 776 - 778

PubMed ID

  • 2874611

Pubmed Central ID

  • 2874611

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2874611


  • eng