Hyaluronic acid-stimulating activity in the pathophysiology of Wilms' tumors.


Journal Article

Markedly elevated levels of hyaluronic acid occur in the serum and urine of some patients with Wilms' tumor. We have recently described a glycoprotein factor in fetal serum that stimulates deposition of hyaluronic acid. In a survey of bovine fetal tissue extracts, we have identified the fetal kidney as the source of this circulating activity. Wilms' tumors arise from transformed "rests" of fetal kidney. We demonstrate here that such tumors continue to produce this fetal factor and that the hyaluronic acid-stimulating activity is found in the urine of children with Wilms' tumors. In the three patients with Wilms' tumor who were followed, elevated levels of hyaluronic acid-stimulating activity were found in their urine before treatment. By 2 months after surgical removal of their tumors, these levels had returned to baseline. We propose that hyaluronic acid-stimulating activity is the mechanism for the elevated levels of hyaluronic acid in the sera and urine of these patients. The activity is an oncofetal protein and the first for which a function has been identified. It also is a marker for this common childhood solid tumor and has the potential for identifying children at increased risk.

Full Text

Cited Authors

  • Longaker, MT; Adzick, NS; Sadigh, D; Hendin, B; Stair, SE; Duncan, BW; Harrison, MR; Spendlove, R; Stern, R

Published Date

  • January 1990

Published In

Volume / Issue

  • 82 / 2

Start / End Page

  • 135 - 139

PubMed ID

  • 2152946

Pubmed Central ID

  • 2152946

Electronic International Standard Serial Number (EISSN)

  • 1460-2105

International Standard Serial Number (ISSN)

  • 0027-8874

Digital Object Identifier (DOI)

  • 10.1093/jnci/82.2.135


  • eng