Endoscopic creation and repair of fetal cleft lip.


Journal Article

In utero repair of several life-threatening malformations in the human fetus is now a clinical reality, yet fetal surgery still poses significant risks to both the mother and the unborn child. Preterm labor is a major problem and is directly related to the large hysterotomy required for fetal exposure. Endoscopic surgical manipulation of the fetus, through small uterine "ports," solves this problem and may eventually permit fetal intervention for non-life-threatening malformations. In this pilot study we demonstrated the feasibility of performing endoscopic surgery on the fetus in situ. A lip incision was created and repaired using endoscopic microsurgical techniques in midgestation fetal lambs. This represents the first application of this technique for in utero fetal intervention.

Full Text

Cited Authors

  • Estes, JM; Whitby, DJ; Lorenz, HP; Longaker, MT; Szabo, Z; Adzick, NS; Harrison, MR

Published Date

  • November 1992

Published In

Volume / Issue

  • 90 / 5

Start / End Page

  • 743 - 746

PubMed ID

  • 1410025

Pubmed Central ID

  • 1410025

Electronic International Standard Serial Number (EISSN)

  • 1529-4242

International Standard Serial Number (ISSN)

  • 0032-1052


  • eng