Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs.


Journal Article

OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.

Full Text

Cited Authors

  • Paek, BW; Farmer, DL; Wilkinson, CC; Albanese, CT; Peacock, W; Harrison, MR; Jennings, RW

Published Date

  • November 2000

Published In

Volume / Issue

  • 183 / 5

Start / End Page

  • 1119 - 1123

PubMed ID

  • 11084552

Pubmed Central ID

  • 11084552

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1067/mob.2000.108867


  • eng