Successful stable xenograft of human fetal hemopoietic cells in preimmune fetal sheep.


Journal Article

Human fetal liver hemopoietic stem cells were transplanted into preimmune fetal sheep. Significant numbers of recipient fetuses showed evidence of engraftment of human stem cells which responded in vivo to human-specific hemopoietic growth factors. The chimerism has persisted now for > 2 years without significant graft loss. No evidence of GVHD has been noted. Successful engraftment was associated with the expression of human erythroid, myeloid, and lymphoid differentiation. This xenograft model offers useful possibilities for the study of the biology of human hemopoiesis in vivo.

Full Text

Cited Authors

  • Zanjani, ED; Pallavicini, MG; Harrison, MR; Tavassoli, M

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 104 /

Start / End Page

  • 181 - 186

PubMed ID

  • 1688260

Pubmed Central ID

  • 1688260

International Standard Serial Number (ISSN)

  • 0066-9458


  • eng