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Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study.

Publication ,  Journal Article
Plantinga, L; Tift, BD; Dunlop-Thomas, C; Sam Lim, S; Barrett Bowling, C; Drenkard, C
Published in: Arthritis Care Res (Hoboken)
October 2018

OBJECTIVE: To use multidomain functional assessment, which is commonly performed in geriatric patients but is novel in patients with systemic lupus erythematosus (SLE), to better understand functional impairment in patients with SLE. METHODS: We recruited 60 adult participants (aged 20-39 years [26.7%], 40-59 years [50.0%], and ≥60 years [23.3%]; 80.0% African American and 90.0% female) from an existing cohort of SLE patients. During in-person visits (from October 2016 to April 2017), we evaluated physical performance (range 0-4, with higher scores indicating better performance), cognitive performance (5 fluid cognition domains; adjusted T scores), and self-reported measures including physical functioning (T scores), activities of daily living (ADLs), falls, and life-space mobility. RESULTS: In the SLE patients, the mean balance score (3.7) and gait speed score (3.4) were high, while the mean lower body strength score was low (1.8). Cognitive performance was average (score of 5.0) for episodic (47.7) and working (48.6) memory and low average for cognitive flexibility (43.7), processing speed (42.6), and attention/inhibitory control (38.8 [>1 SD below average]) when compared with healthy individuals of the same age, sex, race, ethnicity, and education level. Most participants reported the ability to independently perform basic ADLs, but many reported the inability to independently perform instrumental ADLs. Nearly half (45.0%) of participants reported falling in the prior year. Only 40.0% reported unlimited ability to travel without the help of another person. Scores generally did not differ substantially according to age. CONCLUSION: Our results suggest a high prevalence of impairment across multiple domains of function in SLE patients of all ages, similar to or exceeding the prevalence observed in much older geriatric populations. Further research into the added value of geriatric assessment in routine care for SLE is warranted.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

October 2018

Volume

70

Issue

10

Start / End Page

1469 / 1477

Location

United States

Related Subject Headings

  • Prevalence
  • Pilot Projects
  • Physical Functional Performance
  • Mobility Limitation
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Geriatric Assessment
  • Georgia
 

Citation

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Plantinga, L., Tift, B. D., Dunlop-Thomas, C., Sam Lim, S., Barrett Bowling, C., & Drenkard, C. (2018). Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study. Arthritis Care Res (Hoboken), 70(10), 1469–1477. https://doi.org/10.1002/acr.23507
Plantinga, Laura, Benjamin D. Tift, Charmayne Dunlop-Thomas, S. Sam Lim, C. Barrett Bowling, and Cristina Drenkard. “Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study.Arthritis Care Res (Hoboken) 70, no. 10 (October 2018): 1469–77. https://doi.org/10.1002/acr.23507.
Plantinga L, Tift BD, Dunlop-Thomas C, Sam Lim S, Barrett Bowling C, Drenkard C. Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study. Arthritis Care Res (Hoboken). 2018 Oct;70(10):1469–77.
Plantinga, Laura, et al. “Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study.Arthritis Care Res (Hoboken), vol. 70, no. 10, Oct. 2018, pp. 1469–77. Pubmed, doi:10.1002/acr.23507.
Plantinga L, Tift BD, Dunlop-Thomas C, Sam Lim S, Barrett Bowling C, Drenkard C. Geriatric Assessment of Physical and Cognitive Functioning in a Diverse Cohort of Systemic Lupus Erythematosus Patients: A Pilot Study. Arthritis Care Res (Hoboken). 2018 Oct;70(10):1469–1477.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

October 2018

Volume

70

Issue

10

Start / End Page

1469 / 1477

Location

United States

Related Subject Headings

  • Prevalence
  • Pilot Projects
  • Physical Functional Performance
  • Mobility Limitation
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Geriatric Assessment
  • Georgia