ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.

Published

Journal Article

Members of tumor necrosis factor receptor (TNFR) family signal largely through interactions with death domain proteins and TRAF proteins. Here we report the identification of a novel TNFR family member ATAR. Human and mouse ATAR contain 283 and 276 amino acids, respectively, making them the shortest known members of the TNFR superfamily. The receptor is expressed mainly in spleen, thymus, bone marrow, lung, and small intestine. The intracellular domains of human and mouse ATAR share only 25% identity, yet both interact with TRAF5 and TRAF2. This TRAF interaction domain resides at the C-terminal 20 amino acids. Like most other TRAF-interacting receptors, overexpression of ATAR activates the transcription factor NF-kappaB. Co-expression of ATAR with TRAF5, but not TRAF2, results in synergistic activation of NF-kappaB, suggesting potentially different roles for TRAF2 and TRAF5 in post-receptor signaling.

Full Text

Cited Authors

  • Hsu, H; Solovyev, I; Colombero, A; Elliott, R; Kelley, M; Boyle, WJ

Published Date

  • May 1997

Published In

Volume / Issue

  • 272 / 21

Start / End Page

  • 13471 - 13474

PubMed ID

  • 9153189

Pubmed Central ID

  • 9153189

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.272.21.13471

Language

  • eng