ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5.
Members of tumor necrosis factor receptor (TNFR) family signal largely through interactions with death domain proteins and TRAF proteins. Here we report the identification of a novel TNFR family member ATAR. Human and mouse ATAR contain 283 and 276 amino acids, respectively, making them the shortest known members of the TNFR superfamily. The receptor is expressed mainly in spleen, thymus, bone marrow, lung, and small intestine. The intracellular domains of human and mouse ATAR share only 25% identity, yet both interact with TRAF5 and TRAF2. This TRAF interaction domain resides at the C-terminal 20 amino acids. Like most other TRAF-interacting receptors, overexpression of ATAR activates the transcription factor NF-kappaB. Co-expression of ATAR with TRAF5, but not TRAF2, results in synergistic activation of NF-kappaB, suggesting potentially different roles for TRAF2 and TRAF5 in post-receptor signaling.
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Tissue Distribution
- TNF Receptor-Associated Factor 5
- TNF Receptor-Associated Factor 2
- Signal Transduction
- Recombinant Fusion Proteins
- Receptors, Tumor Necrosis Factor, Member 14
- Receptors, Tumor Necrosis Factor
- Proteins
- Protein Sorting Signals
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Tissue Distribution
- TNF Receptor-Associated Factor 5
- TNF Receptor-Associated Factor 2
- Signal Transduction
- Recombinant Fusion Proteins
- Receptors, Tumor Necrosis Factor, Member 14
- Receptors, Tumor Necrosis Factor
- Proteins
- Protein Sorting Signals