Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.

Published

Journal Article

TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a beta-actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases.

Full Text

Cited Authors

  • Khare, SD; Sarosi, I; Xia, XZ; McCabe, S; Miner, K; Solovyev, I; Hawkins, N; Kelley, M; Chang, D; Van, G; Ross, L; Delaney, J; Wang, L; Lacey, D; Boyle, WJ; Hsu, H

Published Date

  • March 2000

Published In

Volume / Issue

  • 97 / 7

Start / End Page

  • 3370 - 3375

PubMed ID

  • 10716715

Pubmed Central ID

  • 10716715

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.050580697

Language

  • eng