Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.
Published
Journal Article
TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a beta-actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases.
Full Text
Cited Authors
- Khare, SD; Sarosi, I; Xia, XZ; McCabe, S; Miner, K; Solovyev, I; Hawkins, N; Kelley, M; Chang, D; Van, G; Ross, L; Delaney, J; Wang, L; Lacey, D; Boyle, WJ; Hsu, H
Published Date
- March 2000
Published In
Volume / Issue
- 97 / 7
Start / End Page
- 3370 - 3375
PubMed ID
- 10716715
Pubmed Central ID
- 10716715
Electronic International Standard Serial Number (EISSN)
- 1091-6490
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.050580697
Language
- eng