Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.


Journal Article

The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.

Full Text

Cited Authors

  • Lacey, DL; Timms, E; Tan, HL; Kelley, MJ; Dunstan, CR; Burgess, T; Elliott, R; Colombero, A; Elliott, G; Scully, S; Hsu, H; Sullivan, J; Hawkins, N; Davy, E; Capparelli, C; Eli, A; Qian, YX; Kaufman, S; Sarosi, I; Shalhoub, V; Senaldi, G; Guo, J; Delaney, J; Boyle, WJ

Published Date

  • April 1998

Published In

Volume / Issue

  • 93 / 2

Start / End Page

  • 165 - 176

PubMed ID

  • 9568710

Pubmed Central ID

  • 9568710

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81569-x


  • eng