Cardiovascular effects of protamine sulfate.


Journal Article

Rapid administration of protamine sulfate after arteriography or cardiopulmonary bypass has occasionally been associated with marked hypotension. Since it is unclear whether this is due entirely to vasodilatation or to myocardial depression in addition to vasodilatation, the authors assessed the direct myocardial and systemic circulatory effects of this drug in seven anesthetized dogs. Direct effects of protamine sulfate on global and regional myocardial function and peripheral arterial resistance were determined in the presence and absence of segmental myocardial ischemia. Effects on the myocardium were determined by intracoronary administration of protamine; effects on the systemic circulation were determined after intravenous administration. Intracoronary administration of protamine caused no significant change in left ventricular contractility in either the normal or ischemic state. Intravenous administration produced hypotension due to peripheral vasodilation.

Full Text

Cited Authors

  • Green, CE; Higgins, CB; Kelley, MJ; Schmidt, WS; Haigler, FH; Newell, JD

Published Date

  • July 1, 1981

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 324 - 329

PubMed ID

  • 7275546

Pubmed Central ID

  • 7275546

Electronic International Standard Serial Number (EISSN)

  • 1536-0210

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-198107000-00014


  • eng