APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.


Journal Article

We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-I signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL-TALL-I and BCMA-TACI form a two ligands-two receptors pathway involved in stimulation of B and T cell function.

Full Text

Cited Authors

  • Yu, G; Boone, T; Delaney, J; Hawkins, N; Kelley, M; Ramakrishnan, M; McCabe, S; Qiu, WR; Kornuc, M; Xia, XZ; Guo, J; Stolina, M; Boyle, WJ; Sarosi, I; Hsu, H; Senaldi, G; Theill, LE

Published Date

  • September 2000

Published In

Volume / Issue

  • 1 / 3

Start / End Page

  • 252 - 256

PubMed ID

  • 10973284

Pubmed Central ID

  • 10973284

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/79802


  • eng