APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-I signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL-TALL-I and BCMA-TACI form a two ligands-two receptors pathway involved in stimulation of B and T cell function.
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Tumor Cells, Cultured
- Transmembrane Activator and CAML Interactor Protein
- T-Lymphocytes
- Spleen
- Recombinant Fusion Proteins
- Receptors, Tumor Necrosis Factor
- Organ Size
- Nuclear Proteins
- Neuropeptides
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Tumor Cells, Cultured
- Transmembrane Activator and CAML Interactor Protein
- T-Lymphocytes
- Spleen
- Recombinant Fusion Proteins
- Receptors, Tumor Necrosis Factor
- Organ Size
- Nuclear Proteins
- Neuropeptides