Biocompatible hydrogels by oxime Click chemistry.


Journal Article

Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.

Full Text

Duke Authors

Cited Authors

  • Grover, GN; Lam, J; Nguyen, TH; Segura, T; Maynard, HD

Published Date

  • October 2012

Published In

Volume / Issue

  • 13 / 10

Start / End Page

  • 3013 - 3017

PubMed ID

  • 22970829

Pubmed Central ID

  • 22970829

Electronic International Standard Serial Number (EISSN)

  • 1526-4602

International Standard Serial Number (ISSN)

  • 1525-7797

Digital Object Identifier (DOI)

  • 10.1021/bm301346e


  • eng