Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds.


Journal Article (Review)

The design of hyaluronic acid (HA)-based hydrogel scaffolds to elicit highly controlled and tunable cell response and behavior is a major field of interest in developing tissue engineering and regenerative medicine applications. This review will begin with an overview of the biological context of HA, which is needed to better understand how to engineer cell-matrix interactions in the scaffolds via the incorporation of different types of signals in order to direct and control cell behavior. Specifically, recent methods of incorporating various bioactive, mechanical and spatial signals are reviewed, as well as novel HA modifications and crosslinking schemes with a focus on specificity.

Full Text

Duke Authors

Cited Authors

  • Lam, J; Truong, NF; Segura, T

Published Date

  • April 2014

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 1571 - 1580

PubMed ID

  • 23899481

Pubmed Central ID

  • 23899481

Electronic International Standard Serial Number (EISSN)

  • 1878-7568

International Standard Serial Number (ISSN)

  • 1742-7061

Digital Object Identifier (DOI)

  • 10.1016/j.actbio.2013.07.025


  • eng