The chicken chorioallantoic membrane model in biology, medicine and bioengineering.

Journal Article (Review;Journal Article)

The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has been shared by specialists working in bioengineering, development, morphology, biochemistry, transplant biology, cancer research and drug development. The tissue composition and accessibility of the CAM for experimental manipulation, makes it an attractive preclinical in vivo model for drug screening and/or for studies of vascular growth. In this article we provide a detailed review of the use of the CAM to study vascular biology and response of blood vessels to a variety of agonists. We also present distinct cultivation protocols discussing their advantages and limitations and provide a summarized update on the use of the CAM in vascular imaging, drug delivery, pharmacokinetics and toxicology.

Full Text

Duke Authors

Cited Authors

  • Nowak-Sliwinska, P; Segura, T; Iruela-Arispe, ML

Published Date

  • October 2014

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 779 - 804

PubMed ID

  • 25138280

Pubmed Central ID

  • 25138280

Electronic International Standard Serial Number (EISSN)

  • 1573-7209

International Standard Serial Number (ISSN)

  • 0969-6970

Digital Object Identifier (DOI)

  • 10.1007/s10456-014-9440-7


  • eng