Gold-nanocrystal-enhanced bioluminescent nanocapsules.

Journal Article (Journal Article)

Metal-enhanced bioluminescence presents a great opportunity to achieve ultrasensitive analysis and imaging with low bioluminescent background and enhanced luminescence. We hereby report metal-enhanced bioluminescence based on bioluminescent protein nanocapsules conjugated with gold nanocrystals. Such gold-nanocapsule complexes exhibit near 10-fold enhancement in bioluminescent intensity and are effectively delivered into the cells with outstanding stability. This work offers a class of bioluminescent nanoparticles for imaging and other applications.

Full Text

Duke Authors

Cited Authors

  • Du, J; Jin, J; Liu, Y; Li, J; Tokatlian, T; Lu, Z; Segura, T; Yuan, X-B; Yang, X; Lu, Y

Published Date

  • October 13, 2014

Published In

Volume / Issue

  • 8 / 10

Start / End Page

  • 9964 - 9969

PubMed ID

  • 25243486

Pubmed Central ID

  • 25243486

Electronic International Standard Serial Number (EISSN)

  • 1936-086X

International Standard Serial Number (ISSN)

  • 1936-0851

Digital Object Identifier (DOI)

  • 10.1021/nn504371h


  • eng